News

  • Prize

    Prize

    We are delighted to share and congratulate Ana Beatriz Caniceiro for receiving the award in the Biochemistry category UC-Life Sciences with her scientific article titled “MUG: A mutation overview of GPCR subfamily A17 receptors” in the Computational and Structural Biotechnology Journal.

  • New Review

    New Review

    In this review, we present a thorough examination of the latest breakthroughs in drug toxicity prediction, highlighting the significance of drug-target binding affinity in anticipating and mitigating possible adverse effects. In doing so, we aim to contribute to the development of more effective and secure drugs. Please check it at ACS Chemical Research in Toxicology 

  • Collaborative Paper

    Collaborative Paper

    Microglial Rac1 is essential for experience-dependent brain plasticity. Rac1 modulates microglia-synapse interaction. Ablation of Rac1 in microglia hampers context-dependent learning, memory, and sociability. Increasing Rac1 signaling might improve cognitive performance in neurological disorders. Check more information in Cell Reports paper.

  • World of dimers

    World of dimers

    Development of a general structural-functional workflow for all GPCR homo- and heterodimers. Detailed conformational/configurational analysis of the dimers. Key residues in TM4 and TM5 are crucial for the stabilization of most dimer interfaces. GPCR activation is influenced by the dimer configuration. Check recent paper in Comput Struct Biotechnol J.

  • Collaborative Paper

    Collaborative Paper

    Endothelial cell function is enhanced by bioactive lipids such as prostacyclin and sphingosine 1-phosphate (S1P) when bound to its chaperone apolipoprotein M (ApoM). Lin et al. generated a fusion protein called A1M to promote both S1P and prostacyclin signaling. A1M consisted of ApoM and ApoA1, a structural component of high-density lipoprotein (HDL) that stabilizes prostacyclin. When…

  • Poseidon

    Poseidon

    We developed POSEIDON, an open-access and up-to-date curated database that provides experimental quantitative uptake values for over 2,300 entries and physicochemical properties of 1,315 peptides. POSEIDON also offers physicochemical properties, such as cell line, cargo, and sequence, among others. By leveraging this database along with cell line genomic features, we processed a dataset of over…