News

  • Collaborative Paper

    Collaborative Paper

    Microglial Rac1 is essential for experience-dependent brain plasticity. Rac1 modulates microglia-synapse interaction. Ablation of Rac1 in microglia hampers context-dependent learning, memory, and sociability. Increasing Rac1 signaling might improve cognitive performance in neurological disorders. Check more information in Cell Reports paper.

  • World of dimers

    World of dimers

    Development of a general structural-functional workflow for all GPCR homo- and heterodimers. Detailed conformational/configurational analysis of the dimers. Key residues in TM4 and TM5 are crucial for the stabilization of most dimer interfaces. GPCR activation is influenced by the dimer configuration. Check recent paper in Comput Struct Biotechnol J.

  • Collaborative Paper

    Collaborative Paper

    Endothelial cell function is enhanced by bioactive lipids such as prostacyclin and sphingosine 1-phosphate (S1P) when bound to its chaperone apolipoprotein M (ApoM). Lin et al. generated a fusion protein called A1M to promote both S1P and prostacyclin signaling. A1M consisted of ApoM and ApoA1, a structural component of high-density lipoprotein (HDL) that stabilizes prostacyclin. When…

  • Poseidon

    Poseidon

    We developed POSEIDON, an open-access and up-to-date curated database that provides experimental quantitative uptake values for over 2,300 entries and physicochemical properties of 1,315 peptides. POSEIDON also offers physicochemical properties, such as cell line, cargo, and sequence, among others. By leveraging this database along with cell line genomic features, we processed a dataset of over…

  • DrugTax

    DrugTax

    DrugTax is our new Python package and scientific paper! By A.J.Preto, Paulo C. Correia and Irina S. Moreira, DrugTax is a chemoinformatics tool that focuses on comprehensible and fast small molecule characterization for analysis and explainable Machine Learning. It can be found and easily installed from PyPI https://pypi.org/project/drugtax/ with the paper on the Journal of…

  • SynPred

    SynPred

    SynPred, a novel Artificial Intelligence based tool to help unveil new drug combinations for cancer treatment has been published by GigaScience, of the Oxford Academic publishing group. By screening different cancer tissues, this tool helps uncover specific solutions that allow the usage of more adequate and less concentrated drugs for cancer treatment. This has a…