NEWS & UPDATES
Stay connected with the latest developments from the Moreira Lab: from breakthrough publications and funding successes to student achievements and cutting-edge computational tools.
We share regular updates on our scientific progress, collaborative projects, student milestones, and the innovative tools emerging from our research. Whether you’re interested in our latest GPCR modelling advances, AI-driven drug discovery breakthroughs, or opportunities to join our dynamic team, this is where you’ll find it all.
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Follow our research tools and code releases on GitHub: MoreiraLAB or contact us for direct collaboration opportunities.
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3D-BioInfo-PT Meeting
Since 2013, 3D-BioInfo-PT has brought together researchers working in bioinformatics, structural, and computational (bio)chemistry in Portugal. The chief goal of 3D-BioInfo-PT is to organize community meetings and provide a space that promotes open scientific discussion, knowledge exchange, and collaboration. Over the years, the annual meetings have become a key event in the communityโs calendar, strengthening…
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AI Transforming Rare Disease Drug Discovery
New Publication Highlight: Amorim AMB, Orzeล U, Caniceiro AB, Rosรกrio-Ferreira N, Moreira ISHow Artificial Intelligence is Changing the Game for Rare Diseases: From Screening to Treatment Trends in Pharmacological Sciences, 2025DOI: 10.1016/j.tips.2025.10.010 Scientific context and contribution Rare diseases affect hundreds of millions of people worldwide, yet drug discovery in this space is hampered by small…
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Collaborative review
RNA Architects of Neuronal Identity Lourinho A, Silva M, Tahiri E, Pinto A, Caniceiro B, Moreira IS, Duarte CB, Costa RORNA architects: how hnRNPs shape neuronal landscapes Brain, 2025, awaf448DOI: 10.1093/brain/awaf448 Scientific context and key findings Neuronal identity, plasticity, and survival rely on exquisitely regulated post-transcriptional RNA control. Among the key regulators are heterogeneous nuclear…
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New Collaborative Publication
Microglial Cytoskeleton and Brain Ageing Portugal CC, Almeida TO, Tedim-Moreira J, Silva C, Canedo T, Galvรฃo J, Magalhรฃes A, Summavielle T, Fassier R, Bai X, Kirchhoff F, Moreira IS, Pinto IM, Costa J, Guedes J, Peรงa J, Socodato R, Relvas JB Disrupting the microglial cytoskeleton accelerates senescence and causes premature synaptic aging Journal of Neuroinflammation,…
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GPCR-A17 MAAP: Mapping Bioactivity with AI
New Publication Highlight Caniceiro A, Amorim AMB, Rosรกrio-Ferreira N, Moreira ISGPCR-A17 MAAP: Mapping Modulators, Agonists, and Antagonists to Predict the Next Bioactive Target Journal of Cheminformatics, 2025, 17, 102DOI: 10.1186/s13321-025-01050-z Scientific context and contribution G proteinโcoupled receptors (GPCRs) remain the most prolific class of drug targets, yet systematically identifying new bioactive ligands and targets across…
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GPCR Crosstalk via Oligomerization
New Publication Highlight: Orzeล U, Barreto CAV, Filipek S, Moreira ISGPCR Oligomerization Across Classes: A2AR-Mediated Regulation of mGlu5R ActivationInternational Journal of Biological Macromolecules, 2025DOI: 10.1016/j.ijbiomac.2025.139880 Scientific context and key findings G proteinโcoupled receptors (GPCRs) do not function solely as isolated monomers. Increasing evidence shows that oligomerization across GPCR classes can profoundly reshape receptor activation, signaling…