Protein-ligand Interactions


In the area of protein-small ligand interactions, we have been working on various systems:

(i)                the PICK1 PDZ domain;

(ii)               the nitric oxide synthase isoforms;

(iii)              the TEM family of β-lactamases;

(iv)              the nicotinamide phosphoribosyltransferases and nicotinamidases;

(v)               Dopamine 2 Receptor.

All these studies result from an interchange of ideas with experimental groups with as a final goal the production of better and more specific inhibitors.